CONTINUED STUDIES IN THE TOXICOLOGY OF DIMETHYL SULFOXIDE (DMSO)

¹ Department of Surgery, University of Oregon Medical School, Portland, Oregon

Rabbits treated with dimethyl sulfoxide (DMSO) by dermal, i.p., i.v. or i.m. routes of therapy demonstrated remarkably few changes in serum constituents when compared with values from control animals. Serum lactic dehydrogenase and creatine phosphokinase levels increased in rabbits treated by direct injection into muscle. A transient rise in serum hemoglobin, total bilirubin and glucose followed parenteral administration of DMSO. Serum lactic dehydrogenase levels remained elevated in those rabbits treated each day with large doses of DMSO administered parenterally. Rabbits treated for 30 days with 1 g/kg/day i.p. or dermally failed to demonstrate lenticular biomicroscopic changes. On the other hand, a dose of 5 g/kg/day developed lens changes whether administered dermally or by i.p. injection. Rabbits treated p.o. with a DMSO dose of 10 g/kg/day for 26 weeks had no inhibition of their liver alcohol dehydrogenase as compared with untreated control animals.

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