JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by IDÄNPÄÄN-HEIKKILÄ, J. E.
Right arrow Articles by SCHOOLAR, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by IDÄNPÄÄN-HEIKKILÄ, J. E.
Right arrow Articles by SCHOOLAR, J. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 176, Issue 3, 752-757, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

PLACENTAL TRANSFER OF DIAZEPAM-14C IN MICE, HAMSTERS AND MONKEYS

JUHANA E. IDÄNPÄÄN-HEIKKILÄ 1, RONALD J. TASKA 1, H. ALTON ALLEN 1, and JOSEPH C. SCHOOLAR 1

1 Texas Research Institute of Mental Sciences, Houston, Texas

Twenty-five mice (13 in early pregnancy and 12 in late pregnancy), 8 hamsters in late pregnancy, and 4 third trimester pregnant Cynomolgus iris monkeys were injected with diazepam-14C and sacrificed at various time intervals. The maternal distribution, the placental transfer and the fetal distribution of diazepam-14C and its metabolites were studied by autoradiography and liquid scintillation counting. he unchanged diazepam-14C was distinguished from the diazepam metabolites by thinlayer chromatography. Diazepam-14C and its metabolites crossed the placental barrier and accumulated in the fetal tissue in all three of the tested species. In mice diazepam-14C and its metabolites accumulated in the fetuses more rapidly in late than in early pregnancy. Fetal monkeys had a high uptake of radioactivity in the peripheral nerves, liver, spinal cord, kidney, lung, fat, cerebellum and plasma. The pronounced uptake and long retention of diazepam and its metabolites in the fetal monkey cerebellum, spinal cord and peripheral nerves may explain the temporary hypoactivity and hypotonicity that has been reported to occur in human infants when their mothers receive diazepam during labor.

Submitted on July 13, 1970
Accepted on November 13, 1970




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
L. G. Costa, L. Steardo, and V. Cuomo
Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects
Pharmacol. Rev., March 1, 2004; 56(1): 103 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Psychiatr. Serv.Home page
M. M. Iqbal, T. Sobhan, and T. Ryals
Effects of Commonly Used Benzodiazepines on the Fetus, the Neonate, and the Nursing Infant
Psychiatr Serv, January 1, 2002; 53(1): 39 - 49.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics.