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Journal of Pharmacology And Experimental Therapeutics, Vol. 176, Issue 2, 472-479, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF NARCOTIC ANALGESICS UPON THE LOCOMOTOR ACTIVITY AND BRAIN CATECHOLAMINE CONTENT OF THE MOUSE

C. R. RETHY 1, C. B. SMITH 1, and J. E. VILLARREAL 1

1 Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan

The relationship between the catecholamine-depleting and locomotor activity-increasing effects of morphine and related drugs was studied in the mouse. Morphine, levorphanol, l-methadone, ketobemidone and meperidine both increased locomotor activity and decreased brain catecholamine content. Thebaine and d-methadone did not alter either locomotor activity or brain catecholamine content. Tolerance developed to the effects of morphine and related analgesics upon both locomotor activity and brain catecholamine content after the repeated administration of either morphine or levorphanol. Pretreatment with naloxone prevented the effects of morphine and related analgesics upon both brain catecholamine content and locomotor activity. Neither tolerance to levorphanol nor pretreatment with naloxone altered the effects of d-amphetamine and dextrorphan upon locomotor activity and brain catecholamine content.

Submitted on February 27, 1970
Accepted on October 14, 1970




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