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Journal of Pharmacology And Experimental Therapeutics, Vol. 176, Issue 2, 464-471, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

NALORPHINE-INDUCED CHANGES IN MORPHINE SELF-ADMINISTRATION IN RHESUS MONKEYS

STEVEN R. GOLDBERG 1, JAMES H. WOODS 1, and C. R. SCHUSTER 1

1 Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan

Small doses of nalorphine (30-300 µg/kg) and naloxone (3-10 µg/kg) markedly increased the rate of i.v. morphine self-administration in morphine-dependent rhesus monkeys; larger doses tended to decrease morphine self-administration. Naloxone was about 10 times more potent than nalorphine in producing these changes. There was evidence of sequential effects, with one dose of nalorphine affecting the response to subsequent doses. After repeated injections of small nalorphine doses, interspersed saline injections increased self-administration rate in some monkeys. Nalorphine, in the range of doses that produced changes in morphine self-administration, had no effect on cocaine self-administration.

Submitted on May 12, 1969
Accepted on October 27, 1970




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