JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DOWNES, H.
Right arrow Articles by KARLER, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DOWNES, H.
Right arrow Articles by KARLER, R.
Journal of Pharmacology And Experimental Therapeutics, Vol. 175, Issue 3, 692-699, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE EXCITATORY EFFECTS OF BARBITURATES

HALL DOWNES 1, ROGER S. PERRY 1, RICHARD E. OSTLUND 1, and RALPH KARLER 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

After i.v. administration in mice, 5-(2-cyclohexylideneëthyl)-5-ethyl barbituric acid and the (+)-isomer of 5-(1,3-dimethylbutyl)-5-ethyl barbituric acid (DMBB) induced tonic extensor seizures preceded by brief tonic flexion. No evidence of depression preceded or accompanied these seizures. In contrast, the (—)-isomer of DMBB induced preanesthetic excitation without tonic seizures and antagonized the seizure activity of the (+)-isomer. (—)-DMBB was slightly more potent than pentobarbital as a central nervous system depressant and had an LD50 over 20 times higher than (+)-DMBB. Depressant barbiturates were more effective antagonists of barbiturate-induced convulsions than were trimethadione and diphenylhydantoin. Phenobarbital was an effective antagonist at \m=1/15\ of its neurotoxic dose 50. Barbiturates that caused preanesthetic excitation without tonic seizures produced simple depression at lower doses than those needed to elicit preanesthetic excitation. On the basis of these studies it is concluded that the depression which accompanies the seizure activity of racemic DMBB is not a necessary concomitant of barbiturate excitation and obscures the full convulsant effect.

Submitted on October 20, 1969
Accepted on August 10, 1970




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
L. J. Voss, J. W. Sleigh, J. P. M. Barnard, and H. E. Kirsch
The Howling Cortex: Seizures and General Anesthetic Drugs
Anesth. Analg., November 1, 2008; 107(5): 1689 - 1703.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
J. H. Lin and A. Y. H. Lu
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development
Pharmacol. Rev., December 1, 1997; 49(4): 403 - 449.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. Huang and J. Barker
Pentobarbital: stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons
Science, January 11, 1980; 207(4427): 195 - 197.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.