RENAL EFFECTS OF URICOSURIC AGENTS IN THE CEBUS MONKEY

¹ Merck Institute for Therapeutic Research, West Point, Pennsylvania

The effects of known uricosuric agents have been examined by standard clearance techniques in male Cebus monkeys. Probenecid was effective in promoting uricosuria at p.o. doses greater than 10 mg/kg. Sulfinpyrasone was only mildly active in this species. Zoxazolamine, at p.o. doses sufficient to produce marked uricosuria in man, was inactive. Phenylbutasone was weakly active; carinamide did not elicit a uricosuric response under our experimental conditions. Iodopyracet at high loads was markedly uricosuric. Chlorothiaside at i.v. doses of 25 mg/kg elicited a biphasic response of uricosuria followed by urate retention. The relative inactivity of certain uricosuric agents in the Cebus monkey is thought to be due to either a basic difference from man in the urate transport system or the result of rapid biotransformation to an inactive metabolite(s), poor oral adsorption or a combination of these.