JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MELLO, N. K.
Right arrow Articles by MENDELSON, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MELLO, N. K.
Right arrow Articles by MENDELSON, J. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 175, Issue 1, 94-112, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics


BEHAVIORAL STUDIES OF SLEEP PATTERNS IN ALCOHOLICS DURING INTOXICATION AND WITHDRAWAL

NANCY K. MELLO 1 and JACK H. MENDELSON 1

1 National Center for Prevention and Control of Alcoholism, National Institute of Mental Health, Chevy Chase, Maryland

Twenty-four-hour sleep patterns of 50 male alcohol addicts were assessed behaviorally during a 5-day base-line period, a 7- to 62-day period of spontaneous drinking and a subsequent alcohol withdrawal phase. Alcohol ingestion produced an increase in total hours of sleep which was associated with two distinctive changes in sleep patterns:1) fragmentation, a tendency to sleep in several short episodes (3-4 hours) instead of a sustained night's sleep; and 2) somnolence, the distribution of consecutive hours of sleep was shifted beyond the base-line mode and long sleep episodes were combined with occasional naps. Fragmentation of sleep patterns was the most reliable correlate of alcohol ingestion and a frequent accompaniment of alcohol withdrawal. However, there were no common sleep distribution patterns during alcohol withdrawal either as a function of symptom severity or type of medication used. Contrary to the prevailing clinical impression, abrupt cessation of drinking did not invariably produce an initial insomnia. Moreover, hallucinosis occurred as a concomitant of the alcohol abstinence syndrome and independent of an antecedent or concurrent state of insomnia. These data are discussed in the context of current models of physical dependence.

Submitted on January 19, 1970
Accepted on June 18, 1970




This article has been cited by other articles:


Home page
J Geriatr Psychiatry NeurolHome page
W. E. Rinn
Mental Decline in Normal Aging: A Review
J Geriatr Psychiatry Neurol, July 1, 1988; 1(3): 144 - 158.
[Abstract] [PDF]




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
 Molecular Interventions Drug Metabolism and Disposition

Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.