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Journal of Pharmacology And Experimental Therapeutics, Vol. 175, Issue 1, 69-74, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

ISOLATION OF MORPHINE-3-GLUCURONIDE FROM URINE AND BILE OF RATS INJECTED WITH CODEINE

S. Y. YEH 1 and L. A. WOODS 1

1 Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City, Iowa

The urine and bile of rats injected s.c. with codeine phosphate were chromatographed on columns of Amberlite XAD-2 and IRC-50 resins. Evaporation of the methanolic effluent gave a residue which was purified by recrystallization from aqueous methanol. Paper and thin-layer chromatography, ultraviolet and infrared spectrophotometry, elemental analyses, morphine and glucuronic acid content established the identity of this product as morphine-3-glucuronide dihydrate. Free codeine, morphine, norcodeine and normorphine were identified in the free alkaloid fraction.

Submitted on October 10, 1969
Accepted on June 15, 1970






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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.