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Journal of Pharmacology And Experimental Therapeutics, Vol. 175, Issue 1, 22-26, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF pH ON PHENOBARBITAL EXTRACTION BY HEMOPERFUSION OVER ANION EXCHANGE RESINS

HARVEY J. SUGERMAN 1 and THOMAS F. NEALON JR. 1

1 Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania

A procedure for the treatment of acute phenobarbital intoxication in dogs by hemoperfusion over anion exchange resins is described. Three hours after i.v. administration of 150 mg/kg of sodium phenobarbital, the dog's blood was pumped at 100 ml/min for one hour over a column containing 750 ml of Amberlite 402, a quaternary amine anion exchange resin. Hemoperfusion at an average arterial pH of 7.30 extracted an estimated 28% of the phenobarbital given. In both the in vitro and in vivo study, the percent extraction correlated significantly with the perfusion pH.

Submitted on August 4, 1969
Accepted on June 2, 1970






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