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Journal of Pharmacology And Experimental Therapeutics, Vol. 175, Issue 1, 206-212, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

STABILIZATION OF EXCITABLE MEMBRANE BY CHRONIC ADMINISTRATION OF DIPHENYLHYDANTOIN

ROBERT M. JULIEN 1 and LAWRENCE M. HALPERN 1

1 University of Washington, School of Medicine, Department of Pharmacology, Seattle, Washington

The action of chronically administered diphenylhydantoin on conduction velocity, excitability thresholds and afterpotentials in isolated rabbit vagus has been examined. After repetitive electrical stimulation, nonmyelinated C fibers in vagus nerves from control athmals exhibit a period of decreased excitability which persisted for approximately 165 seconds and which correlated with the time course of post-tetanic hyperpolarization. Diphenyihydantoin (5-20 mg/kg i.p. three times daily for five days) markedly shortened the recovery period. This was accomplished without accompanying depression of conduction velocity or excitability thresholds. The relationship between post-tetanic hyperpolarization and neural hyperexcitabiity is discussed.

Submitted on December 29, 1969
Accepted on June 20, 1970




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R. Entrikin, K. Swanson, P. Weidoff, G. Patterson, and B. Wilson
Avian muscular dystrophy: functional and biochemical improvement with diphenylhydantoin
Science, March 4, 1977; 195(4281): 873 - 875.
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