THE EFFECTS OF LIDOCAINE, HEXAMETHONIUM AND ALPHA AND BETA ADRENERGIC BLOCKING AGENTS ON THE PULMONARY VEINS IN INTACT DOGS

¹ Cardiopulmonary Laboratory, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana

The active responses of the pulmonary veins of intact dogs to hexamethonium, lidocaine and adrenergic blocking agents were studied with a catheterization technique which permitted pump perfusion of a hemodynamically separated lobe perfused at a constant rate of flow. These active responses in the separated lobe were compared to simultaneously occurring modulated responses in other lobes which were normally perfused. The data indicate that hexamethonium did not dilate the lobar vessels, and that the depressor responses in the normally perfused lobes were passively mediated by decreased blood flow. Lidocaine, administered intralobarly, actively constricted the lobar vessels, but had no detectable effect on the normally perfused vessels. Alpha adrenergic blocking agents, phentolamine and phenoxybenzamine, actively dilated the pulmonary vessels. The responses of the lobar vessels to beta adrenergic blocking agents varied: propranolol actively constricted these vessels, but this response was obscured in the normally perfused lobes by the decreased cardiac output; LB 46 actively dilated the pulmonary vessels; practolol had no detectable effect; and butoxamine had a variable effect.

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