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Journal of Pharmacology And Experimental Therapeutics, Vol. 174, Issue 3, 421-427, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

STUDIES INDICATING A CENTRAL ANTISECRETORY SITE OF ACTION FOR DESMETHYLIMIPRAMINE (DMI)

Robert G. Pendleton 1, Patricia Bartakovits 1, Darlene A. Miller 1, William A. Mann 1, and Peter T. Ridley 1

1 Smith Kline and French Laboratories, Philadelphia, Pennsylvania

Desmethylimipramine effectively inhibited basal (interdigestive) gastric acid secretion in the rat at p.o. doses of 4 to 50 mg/kg. The drug also inhibited acid secretion induced by 2-deoxy-D-glucose in the conscious gastric fistula dog at i.v. doses of 2.5 and 5.0 mg/kg. These doses, however, were ineffective in inhibiting carbachol-induced acid secretion in the Heidenhain pouch dog. Additionally, the 5-mg/kg dose did not block the acid secretion induced by electrical preganglionic vagal stimulation in the anesthetized dog. The results suggest that the gastric antisecretory action of desmethylimipramine is mediated at a site in the central nervous system.

Submitted on November 20, 1969
Accepted on May 10, 1970






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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.