![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
1 Departments of Psychiatry and Pharmacology and the Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina
After the intracisternal administration of 6-hydroxydopamine, brain levels of norepinephrine were reduced significantly with or without pargyline pretreatment. Depletion of dopamine in the central nervous system was found to be enhanced markedly by pargyline administration at higher dose levels of 6-hydroxydopamine. Brain serotonin concentrations were not altered. The effects of 6-hydroxydopamine were long-lasting with the depletion of brain amines persisting at 78 days. After norepinephrine-H3 intracisternally to animals treated with 6-hydroxydopamine, labeled norepinephrine uptake was diminished with a corresponding reduction of deaminated catechols and a marked increased in methylated amines. Tyrosine hydroxylase activity was found to be reduced in brainstem, caudate nucleus and whole brain in 6-hydroxydopamine-treated animals. Conversion of tyrosine-H3 to labeled norepinephrine and dopamine was also markedly diminished. The results support the view that 6-hydroxydopamine produces a "central sympathectomy" when introduced into cerebrospinal fluid.
Submitted on October 27, 1969
This article has been cited by other articles:
|
|
 |
|
  K. Hanrott, L. Gudmunsen, M. J. O'Neill, and S. Wonnacott 6-Hydroxydopamine-induced Apoptosis Is Mediated via Extracellular Auto-oxidation and Caspase 3-dependent Activation of Protein Kinase C{delta} J. Biol. Chem., March 3, 2006; 281(9): 5373 - 5382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Reynolds, R. J. Carter, and A. J. Morton Dopamine Modulates the Susceptibility of Striatal Neurons to 3-Nitropropionic Acid in the Rat Model of Huntington's Disease J. Neurosci., December 1, 1998; 18(23): 10116 - 10127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mailman, R. Ferris, F. Tang, R. Vogel, C. Kilts, M. Lipton, D. Smith, R. Mueller, and G. Breese Erythrosine (Red No. 3) and its nonspecific biochemical actions: what relation to behavioral changes? Science, February 1, 1980; 207(4430): 535 - 537. [Abstract] [PDF]
|
|
|
|
|
|
A. Acheson, M. Zigmond, and E. Stricker Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine Science, February 1, 1980; 207(4430): 537 - 540. [Abstract] [PDF]
|
|
|
|
|
|
T Kasamatsu and J. Pettigrew Depletion of brain catecholamines: failure of ocular dominance shift after monocular occlusion in kittens Science, October 8, 1976; 194(4261): 206 - 209. [Abstract] [PDF]
|
|
|
|
|
|
J. Ahlskog, P. Randall, and B. Hoebel Hupothalamic hyperphagia: dissociation from hyperphagia following destruction of noradrenergic neurons Science, October 24, 1975; 190(4212): 399 - 401. [PDF]
|
|
|
|
|
|
J. E. Ahlskog and B. G. Hoebel Overeating and Obesity from Damage to a Noradrenergic System in the Brain Science, October 12, 1973; 182(4108): 166 - 169. [Abstract] [PDF]
|
|
|
|
|
|
H. S. Akiskal and W. T. McKinney Jr. Depressive Disorders: Toward a Unified Hypothesis: Clinical, experimental, genetic, biochemical, and neurophysiological data are integrated Science, October 5, 1973; 182(4107): 20 - 29. [Abstract] [PDF]
|
|
|
|
|
|
D. E. Redmond Jr., R. L. Hinrichs, J. W. Maas, and A. Kling Behavior of Free-Ranging Macaques after Intraventricular 6-Hydroxydopamine Science, September 28, 1973; 181(4106): 1256 - 1258. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Ligmond and E. M. Stricker Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats Science, September 29, 1972; 177(4055): 1211 - 1214. [Abstract] [PDF]
|
|
|
|
|
|
R. Heikiila and G. Cohen Inhibition of Biogenic Amine Uptake by Hydrogen Peroxide: A Mechanism for Toxic Effects of 6-Hydroxydopamine Science, June 18, 1971; 172(3989): 1257 - 1258. [Abstract] [PDF]
|
|
|
|
|
|
L. Stein and C. D. Wise Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-Hydroxydopamine Science, March 12, 1971; 171(3975): 1032 - 1036. [Abstract] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
