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Journal of Pharmacology And Experimental Therapeutics, Vol. 174, Issue 1, 27-34, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

A CENTRAL EFFECT OF ANGIOTENSIN: RELEASE OF PITUITARY PRESSOR MATERIAL

WALTER B. SEVERS 1, JOAN SUMMY-LONG 1, JAMES S. TAYLOR 1, and JOHN D. CONNOR 1

1 Department of Pharmacology, The Pennsylvania State University, The Milton S. Hershey Medical Center College of Medicine, Hershey, Pennsylvania

A single injection of angiotensin (0.5 µg) into the lateral ventricle of unanesthetized adult rats elevates mean blood pressure approximately 33 mm Hg. This effect, enhanced by hexamethonium administered peripherally, is inhibited by hexamethonium administered centrally. Phenoxybenzamine pretreatment is also inhibitory. Hypophysectomy reduces central pressor activity approximately 50% and ganglionic blockade abolishes the remaining activity. Lesions in the supraoptic nuclei decrease central pressor activity to the values obtained in hypophysectomized animals. Concomitant with its central pressor effect, angiotensin produces neurogenic thirst which can be markedly inhibited by anticholinergic drugs. These data suggest that angiotensin interacts with central neurons to cause release of antidiuretic hormone and polydipsia which, in the absence of compensatory mechanisms, might produce positive water balance.

Submitted on November 25, 1969
Accepted on March 24, 1970




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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.