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1 Department of Pharmacology, Michigan State University, East Lansing, Michigan
After penicillin treatment of nursing rats both p-aminohippurate (PAH) uptake by renal cortical slices and the kidney weight/body weight ratio were increased. Treatment of nursing rats with cycloheximide prevented the increase in PAH slice/medium ratio induced by penicillin. Renal cortical slices from penicillin-treated rats exhibited significantly greater in vitro incorporation of leucine-C14 and glutamine-C14 than did controls. This effect was specific for the cortex and was associated with a significant increase in PAH uptake. Fractionation studies demonstrated that the protein content of all fractions was increased in kidneys from penicillin-treated rats, but only the increase in the 105,000 x g precipitate was statistically significant. Although incorporation of orotic acid-C14 into kidney cortical tissue was significantly enhanced in penicillin-treated rats, this effect was not apparent when factored by renal protein content. Treatment of nursing rats with ammonium chloride significantly increased the kidney weight/body weight ratio but did not stimulate PAH or N-methylnicotinamide transport. The data support the hypothesis that the stimulation of PAH accumulation by penicillin is associated with enhanced synthesis of specific transport proteins.
Submitted on February 16, 1970
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