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Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 2, 399-406, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

HYPOTENSIVE EFFECTS OF CHLORDIAZEPOXIDE, AMOBARBITAL AND CHLORPROMAZINE ON BEHAVIORALLY INDUCED ELEVATED ARTERIAL BLOOD PRESSURE IN THE SQUIRREL MONKEY

HERBERT BENSON 1, J. ALAN HERD 1, W. H. MORSE 1, and R. T. KELLEHER 1

1 Departments of Physiology, Psychiatry and Pharmacology, Harvard Medical School, Boston, Massachusetts; New England Regional Primate Research Center, Southborough, Massachusetts

Hypotensive and behavioral effects of chlordiazepoxide, amobarbital and chlorpromazine were studied in unanesthetized squirrel monkeys whose mean arterial blood pressure had been increased by environmental means. Each monkey had been trained to press a key (respond) under a fixed-ratio schedule of termination of a stimulus associated with noxious stimuli and had developed marked, persistent elevations of mean arterial blood pressure during the behavioral experiments. All three drugs decreased rates of responding and mean blood pressure.

Submitted on August 25, 1969
Accepted on February 10, 1970






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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.