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*DIAZEPAM
Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 2, 364-370, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF DIAZEPAM (VALIUM) ON LEFT VENTRICULAR FUNCTION AND SYSTEMIC VASCULAR RESISTANCE

RONALD M. ABEL 1, RUDOLF N. STAROSCIK 1, and ROBERT L. REIS 1

1 Clinic of Surgery, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland

The effects of intravenous diazepam on left ventricular function and systemic vascular resistance were determined in anesthetized dogs on cardiopulmonary bypass with heart rate and aortic pressure maintained constant. Immediately after diazepam was given an increase in peak isovolumetric left ventricular pressure and dp/dtmax occurred in every animal, and these effects persisted for 30 minutes in 9 of 10 dogs. Forcevelocity and length-tension relations also demonstrated improved cardiac performance after diazepam. Within 45 seconds after the administration of diazepam, a significant decrease in systemic vascular resistance occurred in all animals. A transient rise in resistance toward control levels occurred during the following 3 to 7 minutes, but within 10 minutes after injection, decreases recurred. Since diazepam augments myocardial contractility and produces systemic vasodilatation, it may have a salutary effect when employed as a sedative or tranquilizer drug in patients with impaired cardiac function.

Submitted on December 23, 1969
Accepted on February 25, 1970




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R P. Alston
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Perfusion, April 1, 1992; 7(2): 77 - 88.
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