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Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 2, 265-269, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

THALIDOMIDE: DISPOSITION IN RHESUS MONKEY AND STUDIES OF ITS HYDROLYSIS IN TISSUES OF THIS AND OTHER SPECIES

HERBERT J. SCHUMACHER 1, JAMES G. WILSON 1, JOHN F. TERAPANE 1, and STEPHEN L. ROSEDALE 1

1 Departments of Environmental Health, Pediatrics, Pharmacology and Anatomy, University of Cincinnati and Children's Hospital Research Foundation, Cincinnati, Ohio

Rates of absorption, metabolism and excretion of thalidomide were determined in the female rhesus monkey. The half-life of the drug was virtually the same in monkeys as in pH 7.4 buffer. The absorption of thalidomide administered p.o. was complete after 9 to 12 hours and the time course for the elimination of metabolites was similar to that observed in rabbits. Although thalidomide was metabolized mainly by spontaneous hydrolysis in plasma and muscle of several species, including dog, mouse, rat, rabbit and hamster, the rate of breakdown was considerably greater in liver.

Submitted on April 16, 1969
Accepted on January 28, 1970




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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.