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Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 2, 242-246, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

EPOXIDE INTERMEDIATES IN MICROSOMAL OXIDATION OF OLEFINS TO GLYCOLS

KENNETH C. LEIBMAN 1 and ELSA ORTIZ 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

The oxidation in rabbit liver microsomes of styrene, cyclohexene and indene to epoxides has been demonstrated by gas chromatography, by thin-layer chromatography of the epoxide picrate derivatives and by accumulation of radioactivity in a styrene oxide pool from labeled styrene. Hydration of these epoxides to glycols had previously been demonstrated; in the cases of the cycloalkenes, the glycol products were the same isomers as those formed by overall oxidation of the alkenes. Epoxides are therefore intermediates in the oxidation of these alkenes to glycols in liver microsomes.

Submitted on November 17, 1969
Accepted on February 21, 1970






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