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Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 1, 94-100, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

INTERACTIONS OF Dgr1-TETRAHYDROCANNABINOL WITH BARBITURATES AND METHAMPHETAMINE

ROBERT K. KUBENA 1 and HERBERT BARRY III 1

1 Department of Pharmacology, University of Pittsbvrgh School of Pharmacy, Pittsburgh, Pennsylvania

NIale albino rats were tested for interactions of Dgr1-tetrahvdrocannabinol (Dgr1-THC), a pure, synthesized compound thought to be the principal euphoric constituent of marihuana, with the depressant action of two barbiturates and with the stimulant action of methamphetamine. In a test of spontaneous motor activity in a photocell arena, Dgr1-THC (4 and 16 mg/kg) potentiated the depressant effect of both pentobarbital (10 mg/kg) and barbital (120 mg/kg). The same doses of Dgr1-THC also prolonged sleeping time under pentobarbital (30 mg/kg) and barbital (240 mg/kg). Since barbital is not metabolized, interaction with . Dgr1-THC is attributable to synergetic depressant actions in the central nervous system rather than inhibition of microsomal enzymes. The higher dose of Dgr1-THC (16 mg/kg), which by itself greatly decreased spontaneous motor activity, failed to diminish the stimulant effect of two doses of methamphetamine (0.5 and 2 mg/kg). However, the percentage of animals surviving a toxic dose of methamphetamine (25 mg/kg) was increased by Dgr1-THC (4 and 16 mg/kg). The findings suggest that Dgr1-THC has sedative or tranquilizing actions. enhancing depressant effects of barbiturates and counteracting toxic effects of methamphetamine stimulation. These interactions with other drugs were found even with a low dose of Dgr1-THC (4 mg/kg). which by itself had little effect on spontaneous motor activity.

Submitted on July 15, 1969
Accepted on December 18, 1969




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