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Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 1, 85-93, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE EFFECTS OF MELENGESTROL ACETATE AND HYDROCORTISONE ACETATE ON EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS

MARGARET E. GREIG 1, ANNA J. GIBBONS 1, and GEORGE A. ELLIOTT 1

1 Research Division, The Upjohn Company, Kalamazoo, Michigan

Both melengestrol acetate (MGA)1 and hydrocortisone acetate under our experimental conditions not only prevented the development of experimental allergic encephalomyelitis but also reversed the established disease. MGA was in general superior to hydrocortisone acetate in both prophylactic and therapeutic treatment and showed fewer side effects associated with glucocorticord activity. These observations were demonstrated both clinically and histologically.

Submitted on September 10, 1969
Accepted on February 1, 1970




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