JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HOLMES, D. E.
Right arrow Articles by PIETIE, L. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOLMES, D. E.
Right arrow Articles by PIETIE, L. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 1, 78-84, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF PHENOTHIAZINE DERIVATIVES ON BIOLOGICAL MEMBRANES: DRUG-INDUCED CHANGES IN ELECTRON SPIN RESONANCE SPECTRA FROM SPIN-LABELED ERYTHROCYTE GHOST MEMBRANES

D. E. HOLMES 1 and L. H. PIETIE 1

1 Department of Biochemistry and Biophysics, University of Hawaii, Honolulu, Hawaii

A unique electron spin resonance, nitroxide spin-label probe technique is used to detect interaction between phenothiazine derivatives and bovine erythrocyte ghost membranes. Effects of solubilizing agents before and after reacting the spin label with the ghosts indicate that at least three membrane sulfhydryl sites can be spin labeled. Druginduced changes in electron spin resonance spectra from the spin-labeled membranes suggest that the drugs alter the protein structure of one of the spin-labeled sites.

Submitted on September 29, 1969
Accepted on December 16, 1969






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.