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Journal of Pharmacology And Experimental Therapeutics, Vol. 173, Issue 1, 138-144, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF NICOTINE ON EFFECTIVE AND TOTAL CORONARY BLOOD FLOW IN THE ANESTHETIZED CLOSED-CHEST DOG

GEORG LEB 1, FRANZ DERNTL 1, ERWIN ROBIN 1, and RICHARD J. BING 1

1 Department of Medicine, University of Southern California, Huntington Memorial Hospital, Pasadena, California, and Department of Ex-perimental Medicine, Wayne State University School of Medicine, Detroit, Michigan

Studies in the experimental animal after i. v. injection of nicotine have failed to show a direct relationship between the increments in total coronary blood flow and myocardial oxygen consumption. This might be due in part to the methods employed in the determination of coronary blood flow, which assess total regional flow only, as well as to difficulties in achieving the required hemodynamic steady state. The use of a bolus injection of the diffusible isotope Rb84, together with a coincidence counting technique, obviates these difficulties, as both effective and total coronary blood flow can be measured within a relatively short period of time. Nicotine (100 µg/kg), injected i. v. over one minute in 12 dosed-chest anesthetized dogs, produced significant increases in heart rate, mean aortic pressure, left ventricular work, myocardial oxygen consumption (MVo2), total coronary blood flow (TCF) and effective capillary flow to the heart muscle (ECF) immediately after injection. There was a significant correlation between ECF and MVo2,. The increments in TCF after nicotine administration were in excess of the increase in MVo2, whereas ECF increased almost proportionally to MVo2; this suggests that ECF as measured by this method provides a better index for myocardial oxygen supply than the measurement of TCF. It is felt that the increase in ECF was sufficient to meet the augmented myocardial oxygen demand produced by nicotine.

Submitted on June 19, 1969
Accepted on November 20, 1969




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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.