RENAL TUBULAR TRANSPORT OF 2-DEOXY-d-GLUCOSE IN DOGS AND RATS

¹ Department of Pharmacology, University of Louisville Medical School, Louisville, Kentucky

The renal excretion of 2-deOxy-D-glucose (2DG) in dogs and rats has been studied using the standard clearance and stop-flow techniques. It was found that 2DG was reabsorbed by the renal tubules at an average of 68 to 89% of the filtered loads and that the reabsorption site is in the proximal tubules. The simultaneous administration of D-glucOse at a dose exceeding its maximal tubular transport capacity led to an inhibition of the tubular reabsorption of 2DG. In some cases, administration of D-glucOse changed the negative T value of 2DG to a positive value, indicating tubular secretion. Phlorizin reduced the tubular reabsorption of 2DG and endogenous D-glucose. 2,4-Dinitrophenol at a dose of 1 mg/ kg/ min did not influence the reabsorption of either sugar. Our results indicate that the process of tubular reabsorption of 2DG is the same as that for D-glucose and D-galactose reabsorption.