INTERACTIONS OF ANTI-INFLAMMATORY DRUGS IN CARRAGEENAN-INDUCED FOOT EDEMA OF THE RAT

¹ Central Research Laboratories, SM Company, St. Paul, Minnesota

The effect of nonsteroidal-nonsteroidal and nonsteroidal-steroidal anti-inflamrnatory drug combinations on carrageenan-induced foot edema of the rat was examined. The resultant effect of combinations of hydrocortisone acetate and phenylbutazone, aspirin or indomethacin was significantly greater than the effect produced by each of the component drugs at corresponding doses. In no case did a combination of two nonsteroidal drugs give an effect greater than that produced by either one of the non-steroids given alone at the corresponding dose. Thus, "sparing" activity may be ascribed to a non-steroid when given with hydrocortisone but not when it is given together with a second nonsteroidal anti-inflammatory drug in this assay.