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Journal of Pharmacology And Experimental Therapeutics, Vol. 172, Issue 2, 416-422, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

DAILY RHYTHM IN THE ACCUMULATION OF BRAIN CATECHOLAMINES SYNTHESIZED FROM CIRCULATING H3-TYROSINE

MICHAEL J. ZIGMOND 1 and RICHARD J. WURTMAN 1

1 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

The accumulation of H-catecholamines in brain was measured in rats given i. p. H3-tyrosine (H3-TYR). In animals injected at the same time of day, brain H3-TYR reached a peak within 10 minutes of injection and remained at this level for at least 120 minutes. Brain H3-catecholamine content was highest 60 minutes after injection. However, H3-catecholamine content corrected for the specific activity of H3-TYR during the accumulation period attained its peak within 10 minutes of the injection and remained at this level for the next two hours; this suggests that the newly synthesized catecholamine equilibrates rapidly with one of several brain pools. Animals maintained under light for 12 hr/day received H3-TYR at the middle or end of the daily light or dark period and were killed after 3 or 60 minutes. The accumulation of H3-catecholamine was significantly higher in the middle of the light period than in the dark period when correction was made for fluctuations in the specific activity of tyrosine.

Submitted on May 19, 1969
Accepted on November 3, 1969




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