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1 Departments of Pharmacology, Marquette School of Medicine, Milwaukee, Wisconsin and Tulane University School of Medicine, New Orleans, Louisiana
The Sperber chicken preparation was used to study the transport systems involved in the renal tubular transport of morphine and its metabolite, morphine ethereal sulfate. Cyanine 863 and mepiperphenidol were potent inhibitors of morphine transport. N-methylnicotinamide exerted little inhibitory effect, presumably because it has lower affinity for the transport mechanism. Probenecid had no effect on morphine transport or on the excretioa of morphine ethereal sulfate formed in the kidney. Radioactive morphine ethereal sulfate was prepared biologically and isolated in crystalline form. In striking contrast to the results mentioned above, transport of infused morphine ethereal sulfate was blocked by probenecid. Since probenecid inhibited the transport of the infused metabolite but not the excretion of metabolite formed in renal cells, the functional site of action of probenecid is tbought to be located only at the peritubular border of the cell.
Submitted on August 5, 1969
This article has been cited by other articles:
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  K. M. Shanahan, A. M. Evans, and R. L. Nation Disposition of Morphine in the Rat Isolated Perfused Kidney: Concentration Ranging Studies J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1518 - 1525. [Abstract] [Full Text]
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