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Journal of Pharmacology And Experimental Therapeutics, Vol. 172, Issue 1, 69-76, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

COMPARISON OF DIFFERENTIAL SECRETION OF ADRENAL CATECHOLAMINES BY SPLANCHNIC NERVE STIMULATION AND CHOLINERGIC AGENTS

LARRY R. KLEVANS 1 and GERARD L. GEBBER 1

1 Department of Pharmacology, Michigan State University, East Lansing, Michigan

The venous blood of the in situ acutely denervated cat adrenal gland was analyzed for epinephrine (E) and norepinephrine (NE) by the trihydroxyindole method. A comparison was made of the differential secretion of E and NE produced by frequencies of splanchnic nerve stimulation (SNS) and doses of acetylcholine, dimethylphenylpiperazinium and nicotine which released equivalent amounts of total catecholamines. Total cateeholamines secreted rose as the frequency of SNS or the dose of a drug was increased. Epinephrine, as a percentage of total catecholamines secreted (%E) also rose significantly as the frequency of SNS was increased from 1 to 20 cps. Low-frequency SNS preferentially released NE; whereas, high frequency SNS preferentially released E. In contrast, %E for single i.a. injections of acetylcholine, dimethylphenylpiperazinium and nicotine was not changed as the dose of each agent was increased. Acetylcholine and dimethylphenylpiperazinium preferentially released E. Nicotine released essentially equivalent amounts of E and NE. These data demonstrate that the pattern of adrenal responses evoked by SNS cannot be equated to that evoked by any one of the cholinergic agents studied.

Submitted on August 11, 1969
Accepted on November 21, 1969




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