JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ITO, M.
Right arrow Articles by DUTTA, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ITO, M.
Right arrow Articles by DUTTA, S.
Journal of Pharmacology And Experimental Therapeutics, Vol. 172, Issue 1, 188-195, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF SIX CARDIAC GLYCOSIDES ON THE TRANSMEMBRANE POTENTIAL AND CONTRACTILE CHARACTERISTICS OF THE RIGHT VENTRICLE OF GUINEA PIGS

M. ITO 1, P. B. HOLLANDER 1, B. H. MARKS 1, and S. DUTTA 1

1 The Ohio State University College of Medicine, Department of Pharmacology, Columbus, Ohio

The effects of six glycosides (ouabain, dihydro-ouabain, digitoxin, digoxin, proscillaridin and convallatoxol) on ventricular transmembrane potential and contractile charcteristics were studied in order to compare their mode of action. It has been generally assumed that all glycosides induce similar effects on cardiac muscle, although their effects on transmembrane potentials show wide variations. The potencies of most of the glycosides studied were approximately the same, with dthydro-ouabain having about 1/30 that of the others. The dose-response curves of digitoxin and ouabain were also approximately equal. It was also found that these six glycosides may be divided into two groups : group I, consisting of digitoxin and proscillaridin, showed a dose-related prolongation of the duration of the action potential and time to peak developed tension; and group II, including ouabain and convallatoxol, primarily shortened the plateau of the action potential, whereas digoxin and dihydro-ouabain were essentially without dose-related effects on the duration of the action potential or time to peak developed tension. These results would suggest that all glycosides do not produce similar effects on cardiac cell membranes and tension generating process because of their differences in action as indicated by action potential configuration and time to peak developed tension.

Submitted on July 16, 1969
Accepted on November 18, 1969




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Wasserstrom and G. L. Aistrup
Digitalis: new actions for an old drug
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1781 - H1793.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Nishio, S. W. Ruch, and J. A. Wasserstrom
Positive inotropic effects of ouabain in isolated cat ventricular myocytes in sodium-free conditions
Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2045 - H2053.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.