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Journal of Pharmacology And Experimental Therapeutics, Vol. 172, Issue 1, 154-162, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

MEASUREMENT OF THE ANALGESIC EFFICACY AND POTENCY OF PENTAZOCINE BY THE D'AMOUR AND SMITH METHOD

WILLIAM D. GRAY 1, ARNOLD C. OSTERBERG 1, and THOMAS J. SCUTO 1

1 Department of Experimental Pharmacology, Lederle Laboratories, Pearl River, New York

With suitable adjustment of stimulus strength, the analgesic action of pentazocine may be demonstrated in rats by the method of D'Amour and Smith. Although less readily, the analgesic action of nalorphine, but not that of cyclazocine, could also be detected. At the lowest intensity of stimulation used methotrimeprazine, chlorpromazine and naloxone significantly increased reaction time; however, the effect of naloxone was slight. Phenobarbital and chlorzoxazone, at the doses used, were without effect. The efficacy (maximal analgesic effect produced) and potency (amount of drug required to produce a given degree of analgesia) of morphine were uninfluenced by stimulus strength. The efficacy of meperidune was diminished only at the highest stimulus intensity while its potency remained unchanged. In contrast, both the efficacy and potency of pentazocune were gradually and markedly decreased when the intensity of stimulus was increased. The rank order for potency and efficacy was morphine > meperidine > pentazo cine.

Submitted on September 10, 1969
Accepted on November 11, 1969




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