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Journal of Pharmacology And Experimental Therapeutics, Vol. 172, Issue 1, 115-121, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF C14-ICI 54,450 (MYALEX) IN VARIOUS SPECIES-AN IN VIVO NIH SHIFT

DAVID M. FOULKES 1

1 Imperial Chemical Industries Limited, Pharmaceuticals Division, Research Department, Alderley Park, Macclesfield, Cheshire, England

ICI 54,450, a new nonsteroidal anti-inflammatory agent undergoes metabolism in rats and dogs involving NIH shift migration of the chioro substituent. In monkeys no metabolites of ICI 54,450 other than urinary acyl glucuronides were detected. Serum of all species contained solely unchanged ICI 54,450. The metabolic hydroxylation of ICI 54,450 has been reproduced in part by treatment with pertrifiuoracetic acid.

Submitted on March 17, 1969
Accepted on October 2, 1969






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