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Journal of Pharmacology And Experimental Therapeutics, Vol. 172, Issue 1, 108-114, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

GUANETHIDINE AND RELATED AGENTS. II. METABOLISM BY HEPATIC MICROSOMES AND ITS INHIBITION BY DRUGS

J. R. MITCHELL 1, J. H. CAVANAUGH 1, J. V. DINGELL 1, and J. A. OATES 1

1 Division of Clinical Pharmacology, Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

The metabolism of guanethidine, debrisoquin and guanoxan by an oxygen-and reduced nicotinamide adenine dinucleotide phosphaterequiring enzyme system in hepatic microsomes of the rat is inhibited by desipramine. The metabolism of these compounds also is inhibited by other tricyclic antidepressants, phenothiazines and amines such as metaraminol. The low dose of desipramine required for inhibition in the rat in vivo suggests the possibility of a similar inhibition of the metabolism of drugs by desiprainine in man.

Submitted on February 17, 1969
Accepted on October 29, 1969




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 Arch Gen PsychiatryHome page
A. H. Glassman and J. M. Perel
The Clinical Pharmacology of Imipramine: Implications for Therapeutics
Arch Gen Psychiatry, May 1, 1973; 28(5): 649 - 653.
[Abstract] [PDF]


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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.