JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NEEDLEMAN, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NEEDLEMAN, P.
Journal of Pharmacology And Experimental Therapeutics, Vol. 171, Issue 1, 98-102, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

TOLERANCE TO THE VASCULAR EFFECTS OF GLYCERYL TRINITRATE

P. NEEDLEMAN 1

1 The Edward Mallinckrodt Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri

Tolerance to the blood pressure response of glyceryl trinitrate (GTN) was produced by administration of high doses of GTN three times a day (s.c.). The induction of tolerance was found to be time- and dose-dependent and was reversible with time upon withdrawal from GTN pretreatment. The tolerance phenomenon was present in vascular smooth muscle removed from GTN-treated animals but could not be induced in aorta strips in vitro. There was a parallel shift in the responsiveness of blood pressure and thoracic aorta strip preparations to challenging doses of GTN during tolerance development. On the other hand, tolerance was not produced in uterus or ileum strips from animals treated in vivo with GTN, even though these tissues are normally responsive to GTN.

Submitted on June 9, 1969
Accepted on October 3, 1969




This article has been cited by other articles:


Home page
 NEJMHome page
J. D. Parker and J. O. Parker
Nitrate Therapy for Stable Angina Pectoris
N. Engl. J. Med., February 19, 1998; 338(8): 520 - 531.
[Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.