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Journal of Pharmacology And Experimental Therapeutics, Vol. 171, Issue 1, 103-108, 1970
Copyright © 1970 by American Society for Pharmacology and Experimental Therapeutics

MATURATION OF RENAL ORGANIC ACID TRANSPORT: SUBSTRATE STIMULATION BY PENICILLIN AND p-AMINOHIPPURATE (PAH)

G. H. HIRSCH 1 and J. B. HOOK 1

1 Department of Pharmacology, Michigan State University, East Lansing, Michigan

Maturation of the renal transport system for -aminohippurate (PAH) in rabbits was measured by an in vitro technique. The ability of renal cortical slices to accumulate PAH increased rapidly after two weeks of age, showed a peak at four weeks and then declined to adult levels. Twice daily administration of PAH (200 mg/kg/day i.p.) for seven days to one-week-old rabbits significantly increased PAH uptake by renal cortical slices. Treatment of nursing rats with 200 or 400 mg/kg of PAH daily for three or seven days significantly enhanced PAH uptake in vitro but had no effect on N-methylnicotinamide uptake. Penicillin administration to nursing rats also produced a significant increase in PAH transport, but did not enhance N-methylnicotinamide transport. The data support the hypothesis that treatment of young animals with organic anions leads to selective stimulation of the mechanisms responsible for renal organic acid transport.

Submitted on July 28, 1969
Accepted on October 3, 1969




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Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics.