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Journal of Pharmacology And Experimental Therapeutics, Vol. 170, Issue 2, 281-286, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF PROPRANOLOL ON EPINEPHRINE-INDUCED CHANGES IN CARDIAC RHYTHM AND ARTERIAL POTASSIUM IN DOGS ANESTHETIZED WITH CYCLOPROPANE

H. P. GUTGESELL 1, J. V. TEMTE 1, and Q. R. MURPHY 1

1 Department of Physiology, University of Wisconsin, Madison, Wisconsin

The beta adrenergic blocking agent, propranolol, in a dose of 0.3 mg/kg, was highly effectivein preventing cyclopropane-epinephrine- induced ventricular tachycardia in dogs. It also suppressed epinephrine-induced hyperkalemia. It was concluded that the antiarrhythmic action of propranolol primarily was due to blockade of the direct effects of epinephrine on the myocardium. In view of the small dosage of propranolol needed to block arrhythmias, it is suggested that the antiarrhythmic action is effected through action on beta adrenergic receptors.

Submitted on May 14, 1969
Accepted on September 2, 1969






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.