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Journal of Pharmacology And Experimental Therapeutics, Vol. 170, Issue 2, 232-238, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

IN VIVO MEASUREMENT OF 5-HYDROXYTRYPTAMINE TURNOVER RATE IN THE RAT BRAIN FROM THE CONVERSION OF C14-TRYPTOPHAN TO C14-5-HYDROXYTRYPTAMINE

ROBERT C. LIN 1, E. COSTA 1, N. H. NEFF 1, C. T. WANG 1, and S. H. NGAI 1

1 Departments of Anesthesiology, Pharmacology and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York

During a constant rate infusion of C14-tryptophan, the specific activity of plasma tryptophan and brain 5- hydroxytryptamine increased curvilinearly with time. Since the steady-state concentration of plasma tryptophan (TP) and brain 5-hydroxytryptamine (5-HT) remained unchanged during the infusion, the fractional rate constant for TP (kTP) and brain 5-HT (k5-HT) could be calculated by applying concepts of steady-state kinetics. The product of k5-HT and the brain 5-HT concentration is a measure of the turnover rate of brain 5-HT. The values calculated with this method approximate the turnover rate values obtained with nonisotopic methods.

Submitted on June 6, 1969
Accepted on July 29, 1969




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