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Journal of Pharmacology And Experimental Therapeutics, Vol. 170, Issue 1, 97-107, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF CHRONIC PRETREATMENT WITH PARGYLINE UPON RESPONSES OF THE ATRIAL PACEMAKER AND OF LEFT ATRIAL STRIPS OF GUINEA PIGS TO TYRAMINE, MEPHENTERMINE, d-AMPHETAMINE AND ADRENERGIC NERVE STIMULATION

M. J. ANTONACCIO 1 and C. B. SMITH 1

1 Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Pretreatment of guinea pigs with pargyline for seven days (75 mg/kg every 24 hours) did not affect the responses of isolated left atrial strips or of the atrial pacemaker to norepinephrine. Although pargyline did not alter responses of left atrial strips to field stimulation, responses of the pacemaker to accelerans nerve stimulation were decreased markedly. Responses to the indirectly acting amines-tyramine, mephentermine and-amphetamine—were enhanced. Conversion of -tyramine to BHB R 2R-octopamine was found to be increased after chronic pargyline pretreatment, and atrial norepinephrine content was doubled. Norepinephrine was about 30 times as potent as octopamine on both force and rate. These results do not support the suggestion of Kopin et al. (1965) that after administration of monoamine oxidase inhibitors norepinephrine storage sites accumulate substances which serve as false transmitters of lesser potency than norepinephrine, thereby causing adrenergic blockade. This study indicates that the chronic administration of pargyline has a bretylium-like effect upon adrenergic neurons.

Submitted on May 26, 1969
Accepted on July 31, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.