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Journal of Pharmacology And Experimental Therapeutics, Vol. 170, Issue 1, 117-122, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

ON THE MEASUREMENT OF THE AFFINITY OF PARTIAL AGONISTS FOR RECEPTORS

D. R. WAUD 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

The dissociation constants for the drug-receptor reaction between muscarinic receptors and piocarpine or n-C7H15Ndagger(CH3)3, have been measured in the smooth muscle of guinea-pig ileum. The measurements were obtained from a comparison of the dose-response curves to these partial agonists with the doseresponse curve to a strong agonist, carbachol. The results were compared with those obtained with the use of an irreversible competitive blocking agent. Both approaches gave similar values.

Submitted on May 14, 1969
Accepted on July 31, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.