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Journal of Pharmacology And Experimental Therapeutics, Vol. 17, Issue 5, 357-375, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics

QUANTITATIVE STUDIES IN CHEMOTHERAPY. V INTRAVENOUS VERSUS INTRAMUSCULAR ADMINISTRATION OF ARSPHENAMINE. CURATIVE POWER AND MINIMUM EFFECTIVE DOSE

CARL VOEGTLIN 1 and HOMER W. SMITH 1

1 Division of Pharmacology, Hygienic Laboratory, U. S. Public Health Service

1. The intramuscular administration of arsphenamine and neoarsphenamine is just as efficacious as the intravenous administration of these drugs in the treatment of experimental trypanosomiasis, as judged by both the minimum effective dose and the percentage of survivals of treated animals. The significance of this point in the treatment of human syphilis is discussed.

2. The ratio of the minimum lethal dose to the minimum effective dose M. L. D./M. E. D., is a substantial index to the curative power of a given drug under experimental conditions.

Submitted on January 31, 1921






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Copyright © 1921 by the American Society for Pharmacology and Experimental Therapeutics.