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Journal of Pharmacology And Experimental Therapeutics, Vol. 17, Issue 3, 227-248, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF DRUGS UPON THE OUTPUT OF EPINEPHRIN FROM THE ADRENALS VII. PHYSOSTIGMINE

G. N. STEWART 1 and J. M. ROGOFF 1

1 From the H. K. Cushing Laboratory of Experimental Medicine, Western Reserve University

After the administration of physostigmine, either intravenously or subcutaneously, in cats, the epinephrin output of the adrenals was found to be augmented (to as much as 10 to 15 times the initial output). The stage of augmentation is prolonged and is preceded by a transient diminution.

No evidence was obtained that after section of the splanchnics and other nerves going to the adrenals, physostigmine can increase the epinephrin output by peripheral action.

Submitted on December 20, 1920






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Copyright © 1921 by the American Society for Pharmacology and Experimental Therapeutics.