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Journal of Pharmacology And Experimental Therapeutics, Vol. 17, Issue 2, 129-139, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics


A COMPARISON OF THE ACTION OF CERTAIN DRUGS UPON MUSCULAR WORK IN FROGS

ELEANOR M. SCARBOROUGH 1

1 The Pharmacological Laboratory, London (R. F. H.) School of Medicine for Women, University of London

1. The action of a drug on striated muscle is shown more conclusively by comparison with previous conditions in the same muscle than by the use of two corresponding muscles, since these are not necessarily equally responsive.

2. The direct action of alcohol and veratrine on frog's muscle is to increase temporarily the amount of work done.

3. Cocaine directly depresses striated muscle without any preliminary increase in response.

4. On muscle which is becoming fatigued, caffeine has very slight restorative action, although an obvious increase in excitability occurs in unfatigued muscle.

Submitted on November 22, 1920







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Copyright © 1921 by the American Society for Pharmacology and Experimental Therapeutics.