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Journal of Pharmacology And Experimental Therapeutics, Vol. 169, Issue 2, 264-270, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

BRADYKININ ON ISOLATED GUINEA-PIG TRACHEAL MUSCLE

LOUIS C. IORIO 1 and JAY W. CONSTANTINE 1

1 Department of Pharmacology, Medical Research Laboratories, Chas. Pfizer & Co., Inc., Groton, Connecticut

Experiments were undertaken to characterize fully the effects of bradykinin on isolated guinea-pig tracheal muscle. On repeated exposure to bradykinin, the responses of most tracheal preparations changed from contractions to relaxations. Evidence is presented that this phenomenon is not due to tachyphylaxis and that none of the responses to bradykinin is mediated via adrenergic or cholinergic systems or via the release of histamine or 5-hydroxytryptamine. Bradykinin-induced contractions and relaxations appeared to be related to low and high tissue tone, respectively. High tissue tone, and hence relaxation to bradykinin, was prevented by discontinuing aeration of the tissues. Neither calcium acetylsalicylate nor phenylbutazone blocked contractions evoked by bradykinin. Phenylbutazone, but not calcium acetylsalicylate, reversed bradykinin-induced relaxation selectively and reversibly, a phenomenon which appeared to be related to hypoxia of the tissue.

Submitted on February 12, 1969
Accepted on June 18, 1969






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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.