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Journal of Pharmacology And Experimental Therapeutics, Vol. 169, Issue 2, 224-228, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

DEPENDENCE OF TETRODOTOXIN BLOCKAGE OF NERVE MEMBRANE CONDUCTANCE ON EXTERNAL pH

TOSHIO NARAHASHI 1, JOHN W. MOORE 1, and DONALD T. FRAZIER 1

1 Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina and the Department of Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico

The effectiveness of tetrodotoxin in blocking the peak transient sodium conductance of squid giant axons has been compared at pH 7 and pH 9 under voltage clamp conditions. Tetrodotoxin was much more potent at pH 7 than at pH 9, and the result is compatible with the concept that the cation forms of tetrodotoxin are mainly responsible for the blocking action.

Submitted on March 7, 1969
Accepted on June 19, 1969






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