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Journal of Pharmacology And Experimental Therapeutics, Vol. 169, Issue 1, 80-86, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

INHIBITORY EFFECTS OF ALLOXAN ON MAMMALIAN ADENYL CYCLASE

K. L. COHEN 1 and M. W. BITENSKY 1

1 Department of Medicine, New York University, School of Medicine, New York, New York

The reported antagonism by caffeine of the diabetogenic effect of alloxan prompted examination of a possible action of alloxan on adenyl cyclase. The effects of alloxan on rat liven, heart, kidney and brain and hamster islet cell adenoma adenyl cyclase were studied in in vitro. An assay based on chromatographic isolation of C14-cycic 3', 5'-adenosine monophosphate was used. Alloxan was found to inhibit adenyl cyclase selectively, reversibly and, in part, competitively. Alloxan, in a concentration of 10-3 M, produced about 80% inhibition in all tissues examined. In view of the role of adenyl cyclase in the regulation of insulin secretion, it is felt that the inhibition of this en zyme by alloxan might be related to the molecular mechanism of action of this drug in vivo.

Submitted on January 31, 1969
Accepted on May 8, 1969




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[Abstract] [PDF]


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