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Journal of Pharmacology And Experimental Therapeutics, Vol. 169, Issue 1, 68-73, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

THE ACCUMULATION OF C-SEROTONIN IN THE GUINEA-PIG VAS DEFERENS

NGUYEN B. THOA 1, DONALD ECCLESTON 1, and JULIUS AXELROD 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

C14-serotonin can be taken up by guinea-pig vas deferens tissue after an incubation in vitro. The accumulation is temperature-dependent and saturable and is blocked by cocaine, imipramine and ouabain, drugs known to interfere with the active transport of norepinephrine into the nerve cells, as well as by norepinephrine itself. The indoleamine appears to accumulate in the same intraneuronal sites which store endogenous norepinephrine. About half of the accumulated C14-serotonin is slowly released from the vas deferens within two hours. This release is enhanced by drugs which release norepinephrine, such as reserpine, tyramine, dopamine and norepinephrine. These observations suggest that uptake and storage in the sympathetic nerve terminals of peripheral tissues may not be specific processes for norepinephrine only, but for other normally occurring amines as well.

Submitted on January 27, 1969
Accepted on May 24, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.