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Journal of Pharmacology And Experimental Therapeutics, Vol. 169, Issue 1, 39-45, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

QUANTITATIVE STUDIES OF THE ANTAGONISM OF MORPHINE BY NALORPHINE AND NALOXONE

A. E. TAKEMORI 1, HARVEY J. KUPFERBERG 1, and JACK W. MILLER 1

1 Department of Pharmacology, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota

The in vivo equivalents of pA2 values for morphine-naloxone for antagonism of analgesia and intestinal inhibition in mice were 7.01 and 6.60, respectively. Although the estimation of a "pA2" for morphine-nalorphine was complicated by the latter's agonistic activity, the extrapolated value in the analgesic assay was 6.71. This value was different from a "pA3" of 5.63 obtained for antagonism of intestinal inhibition.

Submitted on August 9, 1968
Accepted on May 31, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.