JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TABER, R. I.
Right arrow Articles by IRWIN, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TABER, R. I.
Right arrow Articles by IRWIN, S.
Journal of Pharmacology And Experimental Therapeutics, Vol. 169, Issue 1, 29-38, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

AGONIST AND ANTAGONIST INTERACTIONS OF OPIOIDS ON ACETIC ACID-INDUCED ABDOMINAL STRETCHING IN MICE

ROBERT I. TABER 1, DOROTHY D. GREENHOUSE 1, JILL K. RENDELL 1, and SAMUEL IRWIN 1

1 Department of Pharmacology, Biological Research Division, Schering Corporation, Bloomfield, New Jersey

The effect of combinations of morphine with methadone, pentazocine and nalorphine on acetic acid-induced stretching in mice has been studied to clarify the nature of the analgesic action of the opioid antagonists. The acetic acid test was found to be equally sensitive to the effects of morphine and nalorphine and less variable than the phenylquinone test. Combinations of methadone or pentazocine with morphine produced summative effects; combinations of morphine and nalorphine, however, did not. The results of the morphine-pentazocine and morphine-nalorphine combination studies were similar to those reported for the analgesic effects of these combinations in man. The morphine-nalorphine interactions produced results in general agreement with a model of competitive dualism. According to this model, nalorphine would be viewed as a partial agonist having high affinity and moderate intrinsic activity for the morphine analgesic receptor. Additional support for the concept of a common analgesic receptor mechanism for morphine and nalorphine was found in experiments showing that morphine-tolerant mice were cross-tolerant to nalorphine and that naloxone, a pure opioid antagonist, blocked the stretching inhibitory effects of morphine and nalorphine to the same extent. The difference found between nalorphine and pentazocine interactions with morphine probably reflects the greater antagonistic potency or higher affinity of nalorphine for the opioid analgesic receptor. In contrast to previous studies, reserpine-like drugs failed to antagonize either morphine or nalorphine analgesia. The validity of selective antagonism of stretching as a measure of clinical analgesia was further discussed.

Submitted on October 30, 1968
Accepted on May 13, 1969




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
R. J. Tallarida, A. Cowan, and R. B. Raffa
Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice
J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 699 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. H. Kamp, R. C. W. Jones III, S. R. Tillman, and G. F. Gebhart
Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice
Am J Physiol Gastrointest Liver Physiol, March 1, 2003; 284(3): G434 - G444.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.