IMPAIRMENT BY d-AMPHETAMINE OF DELAYED MATCHING PERFORMANCE IN MONKEYS

¹ Department of Pharmacology, Albert Einstein College of Medicine, Bronx, New York

The effect of d-amphetamine administration upon performance of delayed matehing for water rein forcement was studied in eight rhesus monkeys. Accuracy decreased with increasing dose. A dose of 0.1 mg/kg of d-amphetamine increased responding, whereas doses of 0.2 and 0.4 mg/kg decreased responding. Under nondrug conditions, increasing the duration of water deprivation prior to testing increased both accuracy and responding. When d-amphetamine and increased deprivation were combined, an interaction between the two variables was found. The results are discussed in terms of the behavioral mode of action of d-amphetamine.