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Journal of Pharmacology And Experimental Therapeutics, Vol. 168, Issue 1, 96-105, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

THE DIRECT EFFECTS OF VASOACTIVE AGENTS ON PULMONARY VEINS. STUDIES OF RESPONSES TO ACETYLCHOLINE, SEROTONIN, HISTAMINE AND ISOPROTERENOL IN INTACT DOGS

ALBERT L. HYMAN 1

1 Cardiopulmonary Laboratory, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana

In the intact dog a catheterization technique, designed to measure vascular pressures and blood volume in a hemodynamically separated lobe perfused at a constant rate of flow, was used to study the active responses of pulmonary veins to small volume infusions of vasoactive compounds. These active responses were compared to simultaneously occurring modulated responses in the other lobes which were normally perfused. These data indicate that serotonin actively constricts both the lobar arteries and veins but suggest that the more gradually active venoconstriction may modulate the more abruptly active constriction of the upstream vessels. Acetylcholine and histamine actively constrict the lobar small veins. Less direct evidence suggests that acetylcholine constricts the lobar arteries as well, but any tendency for histamine to constrict the lobar arteries is obscured by the accompanying venoconstriction. The data indicate that isoproterenol actively dilates the lobar small veins and suggest an active dilation in the lobar arteries. No active responses of larger pulmonary veins near the venoatrial junction were detected.

Submitted on December 30, 1968
Accepted on March 19, 1969




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Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics.