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Journal of Pharmacology And Experimental Therapeutics, Vol. 167, Issue 2, 365-373, 1969
Copyright © 1969 by American Society for Pharmacology and Experimental Therapeutics

SOME EFFECTS OF LOCAL ANESTHETICS ON ISOLATED MITOCHONDRIA

CARL L. JOHNSON 1 and ARNOLD SCHWARTZ 1

1 Department of Pharmacology, Division of Myocardial Biology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas

The effects of a variety of local anesthetics on mitochondrial activities were measured. The latter included oxygen consumption, K+ and Ca++ transport and energy-linked swelling. Inhibition of these processes, particularly K+ transport by low concentrations of local anesthetics, was most pronounced when histone, a basic protein, was employed to induce transport. Histones and local anesthetics may compete for an anionic binding site involved in K+ transport in mitochondria.

Submitted on November 27, 1968
Accepted on March 1, 1969






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